Synthesized from the amino acid tyrosine

In the neuron tyrosine is acted upon by 3 key enzymes.

Tyrosine hydroxylase converts tyrosine into DOPA

DOPA decarboxylase coverts DOPA into dopamine

Dopamine beta hydroxylase converts dopamine to norepinephrine
Action is terminated both by enzymes : MAO located in mitochondria in the presynaptic neuron and COMT located outside the nerve terminal, and a transport pump that removes NE from the synapse and pumps back into the presynaptic neuron for future use. The pump is a site where many drugs work.

Norepinephrine receptor subtypes

NET pump

VMAt2 -packing into vesicles

Alpha 1

Alpha 2a

Alpha 2b

Alpha 2c

Beta 1

Beta 2

Beta 3
Only alpha 2 receptors are presynaptic autoreceptors. Act as a break stopping further NE release.

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Norepinephrine facts to know
Synthesized from the amino acid tyrosine
In the neuron tyrosine is acted upon by 3 key enzymes.
Tyrosine hydroxylase converts tyrosine into DOPA
…
Sheri Spirt, M.D.
Ssdr18@aol.com
Please follow me on Twitter @DrSheriSpirt
www.drsherispirt.com
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