Now strategy for the treatment of treatment resistant depression has been the addition of anti-inflammatory agents, including COX-2 inhibitors, aspirin, and NSAIDS. Statins, used primarily for their lipid lowering properties also have direct anti-inflammatory effects. FIndings: concomitant use of an SSRi and a station was associated with a decreased risk for both psychiatric and general medical hospital contacts.  It was also NOT associated with increases in mortality. Over 870,000 patients were included in the study.